|
T11546 |
HDHODH-IN-1
|
|
Dehydrogenase
|
|
|
|
T9394 |
CHIKV-IN-2
|
|
Dehydrogenase
|
|
CHIKV-IN-2, a chemical compound, exhibits potent inhibitory activity against the enzyme Dihydroorotate Dehydrogenase (DHODH), crucial for pyrimidine synthesis affecting various viruses' replication. It serves as an effec... |
|
T40168 |
DHODH-IN-16
|
|
Dehydrogenase
|
|
DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human). |
|
T14501 |
BAY-2402234
|
|
Dehydrogenase
,
DNA/RNA Synthesis
|
|
BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity. |
|
T9121 |
AG-636
|
|
Dehydrogenase
,
DNA/RNA Synthesis
|
|
AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects. |
|
T8767 |
PfDHODH-IN-2
|
|
Dehydrogenase
,
Parasite
|
|
PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor . It is used an antimalarial agent and can be used for the research of m... |
|
T11020 |
DHODH-IN-11
|
|
Dehydrogenase
,
DNA/RNA Synthesis
|
|
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03. |
|
T2601 |
Vidofludimus
|
SC12267,4sc-101 |
Dehydrogenase
,
DNA/RNA Synthesis
,
Interleukin
|
|
Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH). |
|
T13774 |
ML390
|
|
Others
,
Dehydrogenase
|
|
ML390 exerts its potent differentiation effect on multiple leukemia models. |
|
T1818 |
Tenovin-6
|
Tenovin 6 |
Dehydrogenase
,
Sirtuin
,
Autophagy
|
|
Tenovin-6 is a p53 transcriptional activity agonist. |
|
T1919 |
Tenovin-1
|
Tenovin 1 |
Mdm2
,
Dehydrogenase
,
Sirtuin
,
p53
,
Autophagy
|
|
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination. |
|
T8480 |
Tenovin-6 Hydrochloride
|
|
Dehydrogenase
,
Sirtuin
,
HDAC
,
p53
,
Autophagy
|
|
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator . |
|
T10384 |
Farudodstat
|
ASLAN003 |
Apoptosis
,
Dehydrogenase
,
DNA/RNA Synthesis
|
|
Farudodstat (ASLAN003) is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity. It has the potential to be a first-in-class candidate in AML. |
|
T5013 |
Brequinar
|
Bipenquinate,NSC 368390,DUP785 |
Virus Protease
,
Dehydrogenase
,
DNA/RNA Synthesis
|
|
Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses. |
|
T1159 |
Leflunomide
|
SU101,RS-34821,HWA486 |
Others
,
Dehydrogenase
,
AhR
|
|
Leflunomide (HWA486) is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis. |
|
T12574 |
PTC299
|
Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate |
VEGFR
,
Dehydrogenase
|
|
PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNA translation and selectively inhibits VEGF protein synthesis at t... |
|
T11029 |
HDHODH-IN-5
|
DHODH-IN-7 |
Dehydrogenase
|
|
|
|
T8332 |
Bipenquinate
|
|
Dehydrogenase
|
|
Bipenquinate is a potent and selective inhibitor of dihydroorotate dehydrogenase (DHODH) with IC50 of 20 nM, blocking de novo pyrimidine biosynthesis. |
|
T11025 |
HDHODH-IN-3
|
DHODH-IN-2 |
Dehydrogenase
|
|
hDHODH-IN-3 is an inhibitor of human dihydroorotate dehydrogenase with a pMIC50 value of 8.6. hDHODH-IN-3 can inhibit measles virus replication. |
|
T11019 |
DHODH-IN-1
|
|
Dehydrogenase
|
|
DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway. |
|
T11027 |
DHODH-IN-4
|
|
Dehydrogenase
|
|
DHODH-IN-4 is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor. The IC50 values of PfDHODH and HsDHODH are 4 μM and 0.18 μM, respectively. DHODH-IN-4 has antimalarial activity. |
|
T11023 |
DHODH-IN-14
|
|
Dehydrogenase
|
|
DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis. |
|
T11030 |
DHODH-IN-8
|
|
Dehydrogenase
|
|
DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively. |
|
T11024 |
DHODH-IN-15
|
|
Dehydrogenase
|
|
DHODH-IN-15 is the hydroxyfuran analogue of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH. DHODH-IN-15 can be used for rheumatoid arthritis. |
|
T12438 |
PfDHODH-IN-1
|
|
Dehydrogenase
,
Parasite
|
|
PfDHODH-IN-1 is an analogue of the active Leflunomide metabolite, has antimalarial activity. |
|
T25524 |
IDI-3783
|
|
|
|
IDI-3783 is a mutant-selective inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH). |
|
T25448 |
Genz-669178
|
|
|
|
Genz-669178 is a wild-type inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH). |
|
T25353 |
DSM74
|
DSM 74,DSM-74 |
|
|
DSM74 is a metabolically stable dihydroorotate dehydrogenase inhibitor that has antimalarial activity. |
|
T71061 |
DSM267
|
|
|
|
DSM267 is a novel Plasmodium falciparum Dihydroorotate Dehydrogenase (PfDHODH) Inhibitor. |
|
T69421 |
Hydrolapachol
|
|
|
|
Hydrolapachol is a novel potent and selective inhibitor of schistosoma mansoni dihydroorotate dehydrogenase (smdhodh) |
|
T71865 |
DSM43
|
|
|
|
DSM43 is a dihydroorotate dehydrogenase (DHODH) inhibitor. Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The p... |
|
T27498 |
GSK983
|
GSK-983,GSK 983 |
|
|
GSK983, a potent broad-spectrum antiviral, blocks cell proliferation and dengue virus replication by inhibiting the pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase (DHODH). |
|
T14780 |
BRD9185
|
|
Dehydrogenase
|
|
BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro. |
|
T26900 |
BRD7539
|
BRD-7539,BRD 7539 |
|
|
BRD7539B is a Dihydroorotate dehydrogenase (DHODH) inhibitor . RD7539 shows to target PfDHODH (IC50 = 0.033 μM) selectively over human (Hs) DHODH (IC50 > 50 μM). |
|
T40087 |
DSM502
|
|
|
|
DSM502, a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor, demonstrates potent nanomolar activity against Plasmodium DHODH and Plasmodium parasites, while not inhibiting mammalian DHODHs. |
|
T11547 |
HDHODH-IN-2
|
|
Others
|
|
hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor with anti-inflammatory activity. |
|
T11026 |
DHODH-IN-3
|
|
Others
|
|
DHODH-IN-3 is an effective inhibitor of human dihydroorotate dehydrogenase (HsDHODH) with IC50 value of 261 nM. DHODH-IN-3 binds to the ubiquinone binding cavity in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potenti... |
|
T68343 |
PyrD-IN-14
|
|
|
|
PyrD-IN-14 is an inhibitor of the PyrD protein (a dihydroorotate dehydrogenase (DHODase) involved in pyrimidine biosynthesis) which suppresses bacterial cytotoxicity, biofilm formation, and antibiotic resistance. |
|
T40182 |
Ascochlorin A
|
Acremochlorin A |
|
|
Ascochlorin A, a compound with a dissociation constant (K D) of 3.29 μM, serves as a novel and potent human dihydroorotate dehydrogenase (hDHODH) inhibitor aimed at treating triple-negative breast cancer. |
|
T60409 |
P1788
|
|
|
|
P1788 is a dihydroorotate dehydrogenase (DHODH) inhibitor that can induce DNA damage [1]. |
|
T40291 |
DSM705
|
DSM705 |
|
|
DSM705 is a pyrrole-based inhibitor of Dihydroorotate Dehydrogenase (DHODH). It demonstrates high potency in the nanomolar range against Plasmodium DHODH and Plasmodium parasites, while not interfering with mammalian DHO... |
|
T69743 |
MEDS433
|
|
|
|
MEDS433 is a dihydroorotate dehydrogenase inhibitor (IC50 1.2 nM). MEDS433 inhibited the in vitro replication of hCoV-OC43 and hCoV-229E, as well as of SARS-CoV-2, at low nanomolar range. Notably, the anti-SARS-CoV-2 act... |
|
T62550 |
DSM705 hydrochloride
|
|
|
|
DSM705 hydrochloride is a potent antimalarial compound and a pyrrole-based inhibitor of dihydroorotate dehydrogenase (DHODH).DSM705 hydrochloride shows nanomolar effects against PlasmodiumDHODH and Plasmodium parasites a... |
|
T11813 |
Laflunimus
|
HR325 |
Others
|
|
Laflunimus suppresses immunoglobulin (Ig) secretion, with IC50 values of 2.5 and 2 μM for IgM and IgG, respectively. Laflunimus also is a prostaglandin endoperoxide H synthase (PGHS) -1 and -2 inhibitor. Laflunimus is a... |
|
T82223 |
HDHODH-IN-13
|
|
|
|
hDHODH-IN-13 (compound w2), an inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 of 173.4 nM and has potential research applications in studying inflammatory bowel disease (IBD) [1]. |
|
T72948 |
HDHODH-IN-11
|
|
|
|
hDHODH-IN-11, a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 value of 7.2 nM and has low cytotoxicity. It is applicable in acute myeloid leukemia (AML) research. |
|
T64360 |
HDHODH-IN-8
|
|
Dehydrogenase
|
|
hDHODH-IN-8 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 16 nM. hDHODH-IN-8 has potent antiproliferative activity and excellent aqueous solubility. hDHODH-IN-8 has the potential fo... |
|
T78932 |
HDHODH-IN-12
|
|
DNA/RNA Synthesis
|
|
hDHODH-IN-12 is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), exhibiting an inhibitory concentration (IC50) of 0.421 μM. As the rate-limiting enzyme in the de novo synthesis of pyrimidines, critical for DNA... |
|
T72696 |
UCK2 Inhibitor-3
|
|
|
|
UCK2 Inhibitor-3 is a non-competitive inhibitor targeting uridine-cytidine kinase 2 (UCK2), a key enzyme in the pyrimidine salvage pathway, with an IC50 value of 16.6 μM. Notably, UCK2 can partially substitute for dihydr... |
|
T70899 |
Vidofludimus hemicalcium
|
4sc-101 hemicalcium,SC12267 hemicalcium,4sc-101 hemicalcium ; SC12267 hemicalcium |
|
|
Vidofludimus hemicalcium (4sc-101; SC12267) is an orally active compound that acts as a dihydroorotate dehydrogenase (DHODH) inhibitor and serves as a novel modulator of the farnesoid X receptor (FXR). This immunomodulat... |
